Publications

The most recent publications from our groups

Foxg1 Upregulation Enhances Neocortical Activity

Date: 

7 May, 2020

Foxg1 is an ancient transcription factor gene orchestrating a number of neurodevelopmental processes taking place in the rostral brain. In this study, we investigated its impact on neocortical activity. We found that mice overexpressing Foxg1 in neocortical pyramidal cells displayed an electroencephalography (EEG) with increased spike frequency and were more prone to kainic acid (KA)-induced seizures.

The Uptake of Tau Amyloid Fibrils Is Facilitated by the Cellular Prion Protein and Hampers Prion Propagation in Cultured Cells

Date: 

11 May, 2020

Tauopathies are prevalent, invariably fatal brain diseases for which no cure is available. Tauopathies progressively affect the brain through cell‐to‐cell transfer of tau protein amyloids, yet the spreading mechanisms remain unknown. Here we show that the cellular prion protein (PrPC) facilitates the uptake of tau aggregates by cultured cells, possibly by acting as an endocytic receptor.

Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis

Date: 

1 March, 2019

Foxg1 exerts a pleiotropic control on brain morphogenesis. Mutations in this transcription factor gene lead to a complex neurological syndrome, including brain malformation, EEG anomalies, behaviourial abnormalities and cognitive impairment. This paper describes the key role played by Foxg1 in fine regulation of the balance between neuronal and glial generation within the developing neocortex.