Publications

The most recent publications from our groups

Multidimensional Functional Profiling of Human Neuropathogenic FOXG1 Alleles in Primary Cultures of Murine Pallial Precursors

Date: 

27 February, 2022

FOXG1 is an ancient transcription factor gene mastering telencephalic development. A number of distinct structural FOXG1 mutations lead to the “FOXG1 syndrome”, a complex and heterogeneous neuropathological entity, for which no cure is presently available. Reconstruction of primary neurodevelopmental/physiological anomalies evoked by these mutations is an obvious prerequisite for future, precision therapy of such syndrome.

The Uptake of Tau Amyloid Fibrils Is Facilitated by the Cellular Prion Protein and Hampers Prion Propagation in Cultured Cells

Date: 

11 May, 2020

Tauopathies are prevalent, invariably fatal brain diseases for which no cure is available. Tauopathies progressively affect the brain through cell‐to‐cell transfer of tau protein amyloids, yet the spreading mechanisms remain unknown. Here we show that the cellular prion protein (PrPC) facilitates the uptake of tau aggregates by cultured cells, possibly by acting as an endocytic receptor.

Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis

Date: 

1 March, 2019

Foxg1 exerts a pleiotropic control on brain morphogenesis. Mutations in this transcription factor gene lead to a complex neurological syndrome, including brain malformation, EEG anomalies, behaviourial abnormalities and cognitive impairment. This paper describes the key role played by Foxg1 in fine regulation of the balance between neuronal and glial generation within the developing neocortex.